Generation of Haploid Stem Cells From Human Germ Cells
试验速览
- 阶段
- 不适用
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Patients donated samples
研究概览
简要总结
Human cells are diploid (contain a double set of chromosomes). The diploid genome is complex and therefore limits genetic research approaches in biomedical models. To overcome this problem experimental generation of haploid stem cells has been done in animals. The investigators aim at generating haploid stem cells from human germ cells that are a useful tool in genetic research and screening.
详细描述
Human cells are diploid (contain a double set of chromosomes). The diploid genome is complex and therefore limits genetic research approaches in biomedical models. To overcome this problem experimental generation of haploid stem cells has been done in animal models. haploid cells are easier for genetic manipulations, such as knock-in and knock-out of genes, and therefore should make a better experimental model. The investigators aim at generating haploid stem cells from human haploid germ cells.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •males over the age of 18 and under 50
- •no known chronic illness
- •not taking any chronic drugs
排除标准
- •males under 18 or over 50
- •any known chronic illness
- •taking chronic medications
结局指标
主要结局
Patients donated samples
时间窗: June 2011-November 2013
No samples collected to date
次要结局
- No secomdary outcome(June 2011 - November 2013)