Relationship Between Atelectasis on Ultrasound and PaO2/FiO2

Not Applicable

Completed

• Conditions: Atelectasis, Postoperative
• Interventions: Device: ultrasound

• Registration Number: NCT02499536
• Lead Sponsor: Severance Hospital

Brief Summary

The aim of this study is to find out relationship between PaO2/FiO2 and atelectasis finding on intraoperative lung ultrasound.

Detailed Description

Patients aged 20\~65 with ASA class (American Society of Anesthesiologists physical status classification) 1 or 2 who are scheduled to undergo general anesthesia by using endotracheal intubation and arterial line cannulation will participate in this study. The patients with abnormal chest x-ray finding, pregnancy, arrhythmia, ischemic heart disease will be excluded from this study as well as the patients who are scheduled to undergo lung or heart surgery.

After 5 minutes preoxygenation, patients will be monitored with pulse oxymetry, noninvasive blood pressure. General anesthesia will be proceeded with typical method and endotracheal intubation and arterial cannulation will be proceeded. After ventilator adjustment (tidal volume as 8 times of the patient's ideal body weight), airway pressures(peak and plateau) will be recorded. Subsequently, arterial blood sampling will be proceeded while examination of the atelectasis findings on lung ultrasound before surgery. Lung ultrasound examination will be proceeded on 6 sections of patient's basal segments of the lung, including anterior, lateral, posterior segment. Juxtapleural consolidation, loss of A lines, presence of B lines, air bronchogram, loss of sliding sign and presence of pulse sign on lung ultrasound finding will be investigated and recorded.

Same ultrasound examination and arterial blood sampling will be followed after surgery ends.

The results of PaO2/FiO2 on arterial blood samplings will be compared with findings on lung ultrasound before and after surgery.

Study Timeline

• Study Start: 2015-07
• Study First Submitted: 2015-07-10
• Study First Submitted QC: 2015-07-15
• Study First Posted: 2015-07-16
• Status Verified: 2016-04
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Last Update Submitted: 2016-04-25
• Last Update Posted: 2016-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Patients aged 20~65
• with ASA class 1 or 2
• who are scheduled to undergo general anesthesia by using endotracheal intubation and arterial line cannulation

Exclusion Criteria

• The patients with abnormal chest x-ray finding,
• pregnancy,
• arrhythmia,
• ischemic heart disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Study participants	ultrasound	After general anesthesia development of the atelectasis will be investigated by the lung ultrasound

Primary Outcome Measures

Name	Time	Method
Intraoperative lung ultrasound for atelectasis	Baseline (Before surgery begins) and Postoperative (Just after the surgery ends)	Lung ultrasound examination for atelectasis findings (eg. whether there is a loss of A line or presence of B lines before and after surgery)
Change in PaO2/FiO2	Baseline (Before surgery begins) and Postoperative (Just after the surgery ends)	Arterial blood sampling to find out whether their is a change in PaO2/FiO2 before and after surgery.

Secondary Outcome Measures

Name	Time	Method
Airway pressure change	Baseline (Before surgery begins) and Postoperative (Just after the surgery ends)	To find out if there is any difference between preoperative and postoperative airway pressures(peak and plateau pressure), monitored by ventilator used during general anesthesia in mmHg

Trial Locations

Locations (1)

Gangnam Severance Hospital; 🇰🇷 Seoul, Gangnam-gu, Korea, Republic of