Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cancer Survivor
- Sponsor
- University of Miami
- Enrollment
- 6
- Locations
- 1
- Primary Endpoint
- Vascular Inflammation
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Survivors of childhood cancer have an increased risk of death from cardiovascular disease due to both the therapies they received while undergoing treatment and diet and lifestyle factors. The nature of cardiovascular risk and the interaction between treatment affects and cardiovascular risk factors is unknown. We propose to study vascular inflammatory markers as well as measure of blood vessel stiffness (both of which are predictive of early heart disease) in 100 pediatric cancer survivors and 100 control children. Characterization of vascular inflammation and stiffness in long-term survivors will allow for the development of future interventions to decrease inflammation through both pharmacologic and lifestyle modifications.
Investigators
Tracie L. Miller, MD
Professor of Pediatrics
University of Miami
Eligibility Criteria
Inclusion Criteria
- •6-30 years of age
- •2 years from the completion of therapy for cancer
- •free of active disease
Exclusion Criteria
- •\<6 or \> 30 years of age
- •current cancer treatment or inside of 2 years post treatment
- •Active disease/infection
Outcomes
Primary Outcomes
Vascular Inflammation
Time Frame: single time point at initial visit
All study procedures to assess vascular inflammation will be assessed through specimen sample collection and through procedures such as (echocardiograph)