Skull Bon Variations in Patient with Congenital Unilatral Choanal Atresia

Not yet recruiting

• Conditions: Atresia

• Registration Number: NCT06890442
• Lead Sponsor: Assiut University

Brief Summary

Identify skull bone Associated Anomalies in patients with cngenital unilatral choanal atresia

Detailed Description

Choanal atresia is a rare congenital disorder caused by a failure to develop the posterior nasal cavity (choana), resulting in a missing opening between the nasopharynx and the nasal cavities.It is the most common congenital anatomical abnormality of the nasal cavities with incidence ratio approximately 1/5000-7000 live births

Generally, choanal atresia may affect one or both Choanae, although most studies show that the unilateral form is more common than the bilateral one,and the incidence is higher in females than in males Children with unilateral choanal atresia are subject to unilateral breathing usually have late unilateral nasal obstruction, persistent ipsilateral rhinorrhea, and recurrent rhinosiusitis Previous studies have shown that the ratio of bone to membranous atresia is 9:1; although a detailed review of CT findings with histopathological studies showed that mixed-wall atresia is the most common and is present in 71% of cases, while in 29% of cases we found a pure bone wall Computer tomography (CT) is presently the golden standard in diagnostics of nasal cavity diseases; thus, it can be applied successfully as a tool for assessing anatomical structures

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-06
• Study First Submitted QC: 2025-03-20
• Last Update Submitted: 2025-03-20
• Study First Posted: 2025-03-24
• Last Update Posted: 2025-03-24
• Study Start: 2025-04-01
• Primary Completion: 2026-04
• Study Completion: 2026-05

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• clinical diagnosis of Congenital Unilateral Choanal Atresia

Exclusion Criteria

Patients with severe craniofacial syndromes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Radiological Variations in Skull Bones in Patients with Congenital Unilateral Choanal Atresia: A Cross-Sectional Study"	10_12 month	Degree and Type of Skull Bone Anomalies Presence and extent of bony abnormalities in the skull base (e.g., sphenoid bone asymmetry, pterygoid plate thickening) Degree of nasal cavity narrowing and choanal obstruction Associated maxillofacial bone abnormalities (e.g., septal deviation, maxillary sinus hypoplasia); 2. Measurement of Specific Skull Bone Changes; Thickness of the atretic plate (bony vs. membranous) Asymmetry of pterygoid plates (measured in mm) Deviation angle of the nasal septum (in degrees) Orbital and maxillary asymmetry