Imaging Characteristics of Chronic Lumbar Disc Herniation From the Perspective of Core Muscles and Subcutaneous Fat Tissue Thickness: an Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lumbar Disc Herniation
- Sponsor
- Zhan Yunfan
- Enrollment
- 110
- Locations
- 1
- Primary Endpoint
- core muscles percent fat
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Fat infiltration and atrophy of lumbar muscles are related to spinal degenerative conditions, which can be seen reliably on MRI scans of lumbar disc herniation (LDH) patients. The aim of this study was to investigate the relationship between the degeneration of core muscles, obesity and chronic LDH. Fifty-five healthy volunteers and fifty-five chronic LDH patients (the course of the disease is more than six months) were enrolled. Core muscle percent fat and subcutaneous fat tissue thickness(SFTT) were used as the outcome measure, and logistic regression and independent samples t-test as the analytical methods to compare the relationship of the following five independent variables (erector spinae, rectus abdominis, [transversus abdominal, internal abdominal oblique, and external abdominal oblique muscle], lumbar multifidus, and psoas major muscles) and SFTT with LDH.
Investigators
Zhan Yunfan
ShuGuang Hospita
ShuGuang Hospital
Eligibility Criteria
Inclusion Criteria
- •patients in good physical health; ②patients aged 20 to 55 years, including 20 and 55 years, male or female; ③patients who agree to participate in the study and sign the informed consent.
- •Exclusion criteria:
- •patients who performed lumbar and abdominal muscles exercises in the past; ②patients unable to tolerate magnetic resonance imaging or claustrophobia;
- •patients who are deemed unsuitable for the clinical trial.
- •Removing criteria:
- •patients who decline participation of various reasons;
- •patients unable to comprehend questions asked by the researchers; ③patients intolerant to necessary examinations.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
core muscles percent fat
Time Frame: baseline
Magnetic resonance imaging-guided core muscles percent fat in patients with chronic LDH and healthy volunteers, including erector spinae, rectus abdominis, (transversus abdominal, internal abdominal oblique, and external abdominal oblique muscle), lumbar multifidus, and psoas major muscles was used as the outcome measure
Secondary Outcomes
- Subcutaneous fat tissue thickness(baseline)