The Influence of Testosterone on Experimental Pain Perception and Social Psychological Functioning
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Pain Tolerance
研究概览
简要总结
This trial examined how the administration of exogenous testosterone would influence pain tolerance and other endogenous steroids (i.e. estradiol and progesterone).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
盲法说明
The investigational drug pharmacy providing the sublingual testosterone masked the drugs. Neither the participants nor the investigators knew who was receiving testosterone.
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy college-aged females that are over the age of 18 and younger than 25 will be used for this study.
排除标准
- •The following criteria will exclude a participant from the study:
- •Anyone that has a tree nut allergy.
- •Women that are pregnant or may feel that they may be pregnant or breast-feeding.
- •Anyone taking supplements that may influence their testosterone level.
- •Anyone taking any kind of steroid that may increase their testosterone level.
- •Anyone that smokes tobacco or uses smokeless tobacco.
- •Anyone that reports any condition associated with nerve damage.
- •Anyone that is using hormonal contraceptive.
- •Anyone who was sick or unwell at the time of screening.
- •Each participant completed a Testosterone Pre-Screen form. This form asked each participant individually whether they are taking any drugs or have any conditions that might be exacerbated by testosterone. This form was completed before they signed the consent form and each time they arrived in the lab for an experimental session.
研究组 & 干预措施
Placebo
Placebo
干预措施: Testosterone (Drug)
Testosterone
Sublingual testosterone
干预措施: Testosterone (Drug)
Testosterone
Sublingual testosterone
干预措施: Placebo Syrup (Other)
Placebo
Placebo
干预措施: Placebo Syrup (Other)
结局指标
主要结局
Pain Tolerance
时间窗: 4 hours After Administration
The ischemic discomfort task applied a sphygmomanometer (blood pressure cuff) 5 cm below their elbow. The cuff was inflated to 200 mmHg. Pain tolerance was measured by how long they could tolerate the ischemic discomfort task. However, task was only allowed to last for 6 minutes
次要结局
- Changes Testosterone Levels(Prior to Intervention (Baseline), 15 minutes Post Intervention)
- Changes Progesterone Levels(Prior to Intervention (Baseline), 15 minutes Post Intervention)
- Changes Estradiol Levels(Prior to Intervention (Baseline), 15 minutes Post Intervention)
研究者
Chance Strenth
Principal Investigator
University of New Mexico