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Clinical Trials/NCT01344330
NCT01344330CompletedNot Applicable

Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

Texas A&M University1 site in 1 country108 target enrollmentStarted: January 2012Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
108
Locations
1
Primary Endpoint
Cruciferous vegetable intake correlated with SFN and I3C urinary metabolites
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

This research study will assess cruciferous vegetable intake in patients presenting for screening colonoscopy and correlate intake with histone status and histone deacetylace (HDAC) expression in tissue biopsy specimens and peripheral blood mononuclear cells (PBMCs). The investigators will also measure sulforaphane (SFN) metabolites in blood as a biomarker of cruciferous vegetable intake.

Study Design

Study Type
Observational
Observational Model
Other
Time Perspective
Prospective

Eligibility Criteria

Ages
50 Years to 75 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Cruciferous vegetable intake correlated with SFN and I3C urinary metabolites

Time Frame: At colonoscopy (day 1)

Secondary Outcomes

  • Cruciferous vegetable intake and p21 expression (qRT-PCR, ChIP in PBMCs)(at colonoscopy)
  • Cruciferous vegetable intake correlated with acetylated histone expression (PBMCs, colon tissue),(at colonoscopy)
  • Cruciferous vegetable intake correlated with HDAC activity (in PBMCs)(at colonoscopy)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Roderick Dashwood

Professor, Texas A&M HSC

Texas A&M University

Study Sites (1)

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Cruciferous Vegetable Intake and Histone... | Clinical Trial