DRKS00000780
Completed
Phase 2
Memory, Ageing, and the Cholinergic System a combined fMRI and PET study - MACS
niversitätsklinikum Köln0 sites42 target enrollmentMarch 30, 2011
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- F06.7
- Sponsor
- niversitätsklinikum Köln
- Enrollment
- 42
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •healthy older subjects (age 50\-80 years)
- •patients with mild cognitive impairment (\< 2 SD in Verbal learning and memory test, 50\-80 years)
- •both groups:
- •informed consent
- •normal neurological examination
- •normal physical examination of the body including auscultation of the lungs and heart as well as abdominal palpation
- •normal ECG
- •Systolic blood pressure 100\-160 mmHg
- •Diastolic blood pressure 50\-100 mmHg
- •heart frequency 50\-100
Exclusion Criteria
- •instable cardiovascular diseases, neurologic or psychiatric diseases (except for mild cognitive impairment in the MCI group), insable diseases of the lungs, instable gastrointestinal diseases, instable diseases of the kidneys and the urinary tract, thyreotoxicosis, cancer, pregnancy, breast feeding, persons standing in dependency on the sponsor or investigator, placement into an institution due to governmental or judicial order, participation in other interventional studies potentially interfering with the currrent study, existing therapy with acetylcholinesterase inhibitors, missing secure measure to prevent pregnancy
- •additionally for experiments with Rivastigmin:
- •–hypersensitivity to rivastigmin or other carbamate derivetives
- •–Asthma bronchiale
- •–liver insufficiency
- •–renal insufficiency
- •–coronary heart disease
- •–cardiac rhythm disturbances like bradycardia, tachycardia, Sick Sinus Syndrome
- •–gastric or duodenal ulces
- •–mechanic constipation or mechanic urinary retention
Outcomes
Primary Outcomes
Not specified
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