Risk Factors for Progressive Supranuclear Palsy (PSP)
- Conditions
- Progressive Supranuclear Palsy
- Registration Number
- NCT00431301
- Lead Sponsor
- University of Louisville
- Brief Summary
Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian movement disorder. This study will determine the role of specific genetic, occupational and environmental components in the development of PSP by evaluating patients with this disorder and age and gender matched controls.
- Detailed Description
This proposal will determine: (1) if there is an association between PSP and specific genes of interest; (2) if there is an association between PSP and occupational and/or environmental chemical exposures functionally or structurally similar to known parkinsonian toxicants; and (3) if hypertension or traumatic brain injury prior to symptom-onset is associated with PSP. To disentangle the complex etiology of PSP, this case-control multicenter study involves 500 PSP cases, 500 age/gender matched primary controls, and 500 secondary controls for genetic confirmation. Understanding the etiology of PSP may also help explain the causes of other related diseases such as Alzheimer's disease. This multidisciplinary team of movement disorder specialists, epidemiologists, geneticists, biostatisticians, industrial hygienist and toxicologist is well suited to unravel the etiology of PSP.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 942
- PSP patients able to visit one of the screening sites for diagnostic confirmation and able to participate in a one hour telephone interview
- No other major neurological disorders
- Unable to communicate by telephone
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (10)
University of Colorado
🇺🇸Aurora, Colorado, United States
Emory College of Medicine
🇺🇸Atlanta, Georgia, United States
Rush University
🇺🇸Chicago, Illinois, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
University of Maryland
🇺🇸Baltimore, Maryland, United States
Case Western University
🇺🇸Cleveland, Ohio, United States
University of Toronto
🇨🇦Toronto, Ontario, Canada
University of Alabama, Birmingham
🇺🇸Birmingham, Alabama, United States
UCLA
🇺🇸Los Angeles, California, United States
University of Kansas
🇺🇸Kansas City, Kansas, United States