Correlation of Preoperative Serum and Intraoperative Peritoneal Washing Fluid CA-125 Levels With Postoperative Tumor Histology in Patients With Endometrial Carcinoma: a Prospective-controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Endometrial Carcinoma
- Sponsor
- Erdemli State Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Abdominal washing fluid CA-125 levels
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
In this prospective study, we aimed to investigate whether serum and abdominal washing fluid CA-125 levels correlated with postoperative histopathological parameters in patients with endometrial carcinoma.
Detailed Description
Endometrial cancer was diagnosed with histopathological examination of the samples obtained by dilatation and curettage. Preoperative serum CA-125 levels were determined in all patients. Serum and abdominal washing fluid CA-125 levels were measured with a double antibody sandwich immunoenzymatic method, using Beckman Coulter DXI (Ireland) analyzer. In addition to routine preoperative investigations, MRI was done in patients who were thought to have an extension outside the uterus. During surgery, abdominal exploration was performed first, and then an abdominal fluid sample was obtained for cytological examination and measurement of CA-125 level. One hundred milliliters of normal saline was used as the abdominal washing liquid to obtain the sample for CA-125 measurement. Subsequently, total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH + BSO) were performed.
Investigators
Suleyman Gunhan Doluoglu
Gynecologist
Erdemli State Hospital
Eligibility Criteria
Inclusion Criteria
- •Women with endometrial carcinoma
Exclusion Criteria
- •Previous history of any other malignancy
- •Endometriosis
- •Diagnosed with pelvic infection or with any other potential disease such as acute pancreatitis, colitis, diverticulitis, pericarditis, polyarteritis nodosa, Sjögren's syndrome and SLE
Outcomes
Primary Outcomes
Abdominal washing fluid CA-125 levels
Time Frame: One year