Changes of the myocardium in heart failure with preserved ejection fraction: unravelling the role of epicardial adipose tissue

• Conditions: heart failure; reduced functioning of the heart; 10019280

• Registration Number: NL-OMON56541
• Lead Sponsor: Amsterdam UMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 400

Inclusion Criteria

- Patients undergoing elective cardiac surgery with cardiopulmonary bypass
- Legally competent, willing, and able to sign informed consent

Exclusion Criteria

- Hemodynamically stable, no inotropic/vasopressic and/or mechanical support
prior to surgery.
- Active infection or inflammation, e.g. endocarditis, pericarditis
- Chronic use of anti-inflammatory medication, e.g. steroids;
- Age <18 years

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are EAT-mediated inflammatory biomarkers and their<br /><br>association with clinical parameters for HFpEF, as well as their interaction<br /><br>with cardiomyocyte/endothelium structure and/or function.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study paramaters are:<br /><br>- Differences in inflammatory markers between EAT and subcutaneous adipose<br /><br>tissue (EAT) samples and secretomes<br /><br>- Inflammatory biomarkers in plasma and the different with nflammatory<br /><br>biomarkers in EAT samples</p><br>