Study Aiming to Collect Skin Samples of Diabetic Patients and Healthy Volunteers for Cellular Reprogramming, Within the Framework of New Therapeutic Strategies in Diabetes Treatment
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Type 2 Diabetes
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Nothing will be measured, the aim of the study is the obtention of skin micro-samples collected from healthy volunteers and diabetic patients (type 2 and MODY), intended to be used afterwards to obtain stem cell lines.
- Status
- Terminated
- Last Updated
- 13 years ago
Overview
Brief Summary
The main objective of this study is the Obtention of skin micro-samples collected from healthy volunteers and diabetic patients (type 2 and MODY), intended to be used afterwards to obtain stem cell lines, in the framework of new therapeutic strategies of type 2 diabetes.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diabetic patients diagnosed for type 2 diabetes, with a BMI between 20 and 25, without familial history and known genetic cause of diabetes.
- •Diabetic patients diagnosed for MODY diabetes (1, 2, 3, 4, 5 or 6), with a BMI between 20 and
- •Healthy volunteers, siblings of MODY patients (1, 2, 3, 4, 5 or 6).
- •Healthy volunteers without familial history of diabetes.
- •Patients over 18 years old.
- •Patients with social insurance coverage
- •Patients who signed a consent form
Exclusion Criteria
- •Type 1 diabetic patients.
- •Pregnant women or women who might get pregnant
Outcomes
Primary Outcomes
Nothing will be measured, the aim of the study is the obtention of skin micro-samples collected from healthy volunteers and diabetic patients (type 2 and MODY), intended to be used afterwards to obtain stem cell lines.
Time Frame: patients will be followed for the duration of hospital stay, an expected average of 2 hours.
* Each patient will have a consultation at the hospital. During this consultation, if the patient agrees to participate in the study, the doctor will make him/her sign a consent form and an appointment will be scheduled with the dermatologist for the skin biopsy. * The dermatologist will perform the skin biopsy, the sample will then be carried to the Evry genopole, where the derivation of dermal fibroblasts will be done, and the cells will then be sent to iPierian center, in California, which will take care of the obtention of cell lines.