Role of MAGNETIC RESONANCE IMAGING in Characterization of Superficial Soft Tissue Masses
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Soft Tissue Masses
- Sponsor
- Assiut University
- Enrollment
- 50
- Primary Endpoint
- benign and malignant masses
- Last Updated
- 4 years ago
Overview
Brief Summary
This study responds to these raise up questions: Can we use Diffusion Weighted MR complemented with numerical ADC values & in association with routine MRI in the discrimination between different malignant and benign superficial soft tissue masses.
Detailed Description
In the clinical practice, there is a large number \& variety of superficial soft tissue masses. The differentiation of such masses represents a major obstacle for the surgeons. Benign \&malignant neoplasms as well as non-neoplastic swellings may have similar clinical presentation. The differentiation between malignant \& benign superficial soft tissue neoplasms is required for appropriate therapeutic planning and decisions. Masses can be characterized in terms of their size, number, component \&vascularity using US and Doppler US. However, US is operator dependent \& may display a number of artifacts that can result in misinterpretation. So MRI is superior in the assessment of such soft tissue masses due its brilliant soft tissue discrimination. Some features that will help distinguish malignant from benign lesions are evident on MRI examination such as signal characteristics,enhancement pattern,margin,lobulation,necrosis, haemorrhage,internal septation,peritumoral edema and extension through the deep fascia .However very forcful tumors may show benign behavior \& appear similar to benign masses , Thus further histopathology is required for accurate diagnosis. Diffusion weighted MRI visualizes the random microscopic motion of molecules. Diffusion-weighted imaging (DWI) is the technique which allows measurement of the Brownian motion of water in the tissue microenvironment depending on the organization of the tissue, integrity of cell membranes, and tortuosity of extracellular space. Apparent Diffusion Coefficient (ADC) is a numerical parameter which is calculated from DWI. Previously, DWI technique was used with great success in the central nervous system (CNS), in the differentiation between benign and malignant tumors in addition to its great value in early diagnosis of recent strokes. Nowadays, DWI was used in the differentiation between malignant and benign soft tissue masses. Malignant tumors have abundant cellularity than benign tumors hence they have more restricted diffusion. The addition of quantitative ADC values plays a fundamental role in more accurate diagnosis of malignant superficial soft tissue neoplasms.
Investigators
Fatma Alzahraa Mohamed Hassan Anwar
resident
Assiut University
Eligibility Criteria
Inclusion Criteria
- •patients with superficial soft tissue masses clinically
- •patients underwent us detection of superficial soft tissue masses
- •uncharactized superficial soft tissue mass by other modalities
Exclusion Criteria
- •MRI claustrophobia
- •recurrent cases
- •patients under treatment
Outcomes
Primary Outcomes
benign and malignant masses
Time Frame: from october 2021 to october2022
The discrimination between benign and malignant superficial soft tissue mass by Non invasive available technique
Secondary Outcomes
- Type of malignant superficial soft tissue masses(From October 2021 to October 2022)