Bendamustine-based Combination Therapy for PCNSL

Phase 2

• Conditions: PCNSL
• Interventions: Drug: R-B(O)AD

• Registration Number: NCT03392714
• Lead Sponsor: Chonnam National University Hospital

Brief Summary

This pilot study will i) evaluate the efficacy and the safety of bendamustine-based combination chemotherapy and ii) investigate the pharmacokinetics (PK)of bendamustine in plasma and CSF when given as salvage treatment for patients with relapsed or refractory primary central nervous system lymphoma (PCNSL).

Detailed Description

A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. Based on the demonstrated activity and proposed additive mechanisms of the chemotherapeutic agents included in the bendamustine-based combination regimen, the efficacy and safety of R-B(O)AD will be evaluated for treatment of relapsed/refractory (R/R) primary CNS lymphoma. Evidence from previous preclinical tissue distribution studies and single agent intravenous drug therapy trials in CNS malignancies suggests that bendamustine penetrates brain and tumor tissue, however there are no clinical data available on the PK of bendamustine in the CSF. This study will evaluate the PK of plasma and CSF drug levels through a population based nonlinear mixed-effects model approach in a R/R PCNSL cohort with the goals to define the currently unknown PK profile of bendamustine in the CSF and to further characterize the relationship between plasma and CSF drug levels, and the influence of exposure on response to therapy.

Study Timeline

• Study Start: 2016-01-20
• Study First Submitted: 2017-12-06
• Status Verified: 2018-01
• Study First Submitted QC: 2018-01-02
• Last Update Submitted: 2018-01-02
• Study First Posted: 2018-01-08
• Last Update Posted: 2018-01-08
• Primary Completion: 2018-01-20
• Study Completion: 2019-01-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1. PCNSL of diffuse large B-cell lymphoma (DLBCL) with a CNS lesion by tissue biopsy
2. Age ≥ 19 years old
3. Relapsed or refractory PCNSL after frontline combined chemotherapy or radiation
4. ECOG performance status 0-2
5. Absolute neutrophil count ≥ 1000/uL
6. Platelets ≥ 100,000/uL
7. Total bilirubin ≤ 1.5 x ULN (upper limit of normal)
8. Aspartate aminotransferase (AST) ≤ 3 x ULN
9. Creatinine ≤ 2.0 x ULN

Exclusion Criteria

1. PCNSL of other than DLBCL or T-cell lymphoma with a CNS lesion by tissue biopsy
2. Any of the following: pregnant women, nursing women, men or women of childbearing potential who are unwilling to employ adequate contraception
3. Uncontrolled infection
4. Therapy with myelosuppressive chemotherapy or biologic therapy < 21 days prior to registration
5. Persistent toxicities ≥ grade 3 from prior chemotherapy or biologic therapy regardless of interval since last treatment
6. History of thromboembolic episodes ≤ 3 months prior to registration
7. Active hepatitis B or C with uncontrolled disease
8. Active other malignancy requiring treatment that would interfere with the assessments of response of the lymphoma to protocol treatment
9. Any severe and/or uncontrolled medical conditions or other conditions that could adversely impact their ability to participate in the study
10. Major surgery ≤ 4 weeks prior to registration or have not recovered from side effects of such therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
R-B(O)AD	R-B(O)AD	Intravenous R-B(O)AD every 4 weeks for up to 4 cycles

Primary Outcome Measures

Name	Time	Method
Overall response rate (ORR)	2 year	rate of complete or partial response (CR/PR)

Secondary Outcome Measures

Name	Time	Method
Toxicity based on NCI Common Terminology Criteria version 4.0	2 year	adverse event incidence of combination regimen
Progression-free survival (PFS)	2 years	calculated from the time of study entry until progression, relapse, or death
Overall survival (OS)	2 years	calculated from the time of study entry until death
Maximum concentration [Cmax] of bendamustine in plasma and CSF	6 months	peak concentration of bendamustine after 1 hour IV infusion
Area under the curve [AUC] of bendamustine in plasma and CSF	6 months	overall exposure of bendamustine after IV infusion

Trial Locations

Locations (1)

Chonnam National University Hwasun Hospital; 🇰🇷 Hwasun-gun, Jeollanam-do, Korea, Republic of