The effect of saffaron tablet on the level of inflammatory markers with knee osteoarthritis patients
- Conditions
- Knee Osteoarthritis.Bilateral primary osteoarthritis of knee
- Registration Number
- IRCT2016091029777N1
- Lead Sponsor
- Vice chancellor for research, Golestan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Knee osteoarthritis patients based on American College of Rheumatology(ACR) diagnostic criteria with an intensity of 2 to 3 according to Kellgren and Lawrence(KL) radiography grade, Patients with an average age of 50 to 70 years old;
Exclusion criteria: Known hypersensitivity to Saffron, Patients with other rheumatologic diseases, Patients with active malignant disease or infection, Patients with known mental illness, Patients with a history of recent Knee surgery and severe trauma(within 6 months), Patients with hip osteoarthritis, Patients with septic arthritis, Patients with active gastrointestinal bleeding or a history of it, Patients with chronic kidney disease when the estimated Glomerular Filtration Rate(GFR) is less than 30 ml/min/1.73m2, Severe leukopenia, Patients requiring long term use of corticosteroids such as asthma or inflammatory bowel disease.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum levels of TNF alpha. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: pg/ml.;Serum levels of IL 1 beta. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: pg/ml.
- Secondary Outcome Measures
Name Time Method The intensity of osteoarthritis. Timepoint: Baseline and sixth and twelfth weeks. Method of measurement: WOMAC questionnaire.