A Comparative Study Between Honey and Alcohol as Topical Skin Disinfectant
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Assess efficacy of honey as a disinfectant in comparison to the standard disinfectant which is alcohol
研究概览
简要总结
Skin antisepsis is essential in every healthcare environment. Alcohol/chlorhexidine use might disrupt skin microbiota and lead to antibiotic resistance.
This study investigates honey (being natural product with many beneficial therapeutic effects) as topical skin anti-septic agent and compares it with alcohol, in terms of effectiveness and safety.
详细描述
Recent years' investigations of the co-evolution and functional integration of the human body and its commensal microbiota have disclosed that the microbiome has a major impact on physiological functions including protection against infections.
Invasive procedures such as injections, punctures or surgeries penetrate the skin's natural protective barrier, which may allow pathogenic microorganisms to enter deeper skin layers and cavities and trigger infections there.
Alcohols usually in the form of 70% isopropyl alcohol or 60 to 80% ethyl alcohol, are commonly used topical disinfectants.
Despite being efficiently broad-spectrum antiseptic, Alcohol shows some local hazards affecting skin integrity and microbiome.
Honey has been used in wound care since ancient. It has many beneficial therapeutic effects, including anti-microbia, antioxidant, immune-modulator, wound healing and synbiotic effects .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 2 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Children aged from 2 to 12 years, of both sexes, and with apparently healthy skin.
- •Children, who did not receive any form of antimicrobial agent for at least one-week prior study.
排除标准
- •- Immuno-compromised due to diseases or drugs.
- •- Children having any skin disease as eczema or others
结局指标
主要结局
Assess efficacy of honey as a disinfectant in comparison to the standard disinfectant which is alcohol
时间窗: 3 months
taking a swab from skin for culture of organisms after application of either alcohol or honey and compare type of organisms and number of colony forming units
次要结局
未报告次要终点