The Benefit of Minocycline on Negative Symptoms in Schizophrenia: Extent and Mechanisms
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 207
- 主要终点
- Severity of negative symptoms of psychosis
研究概览
简要总结
The purpose of this study is to investigate if minocycline limits the development of negative symptoms in early psychosis and to test via what mechanism of action this change occurs.
详细描述
Background
Negative symptoms of psychosis do not respond to the traditional therapy with first- or second-generation antipsychotics and are among main causes of a decrease in quality of life observed in individuals suffering from the disorder. Minocycline, a broad-spectrum tetracyclic antibiotic displaying neuroprotective properties has been suggested as a new potential therapy for negative symptoms. In the two previous clinical trials comparing minocycline and placebo, both added to the standard care, patients receiving minocycline showed increased reduction in negative symptoms. Three routes to neuroprotection by minocycline have been identified: neuroprotection against grey matter loss, anti-inflammatory action and stabilisation of glutamate receptors. However, it is not yet certain what the extent of the benefit of minocycline in psychosis is and what its mechanism is. This proposal is for a multi-centre double-blind randomised placebo-controlled clinical trial entitled The Benefit of Minocycline on Negative Symptoms of Psychosis: Extent and Mechanism (BeneMin).
Methods
After providing informed consent, 226 participants in the early phase of psychosis will be randomised to receive either 100 mg modified-release capsules of minocycline or similar capsules with placebo for 12 months in addition to standard care. The participants will be tested for outcome variables before and after the intervention period. The extent of benefit will be tested via clinical outcome measures, namely the Positive and Negative Syndrome Scale score, social and cognitive functioning scores, antipsychotic medication dose equivalent and level of weight gain. The mechanism of action of minocycline will be tested via blood screening for circulating cytokines and magnetic resonance imaging with three-dimensional T1-weighted rapid gradient-echo, proton density T2-weighted dual echo and T2*-weighted gradient echo planar imaging with N-back task and resting state. Eight research centres in the United Kingdom (UK) and 15 National Health Service Trusts and Health Boards will be involved in recruiting participants, performing the study and analysing the data.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 16 Years 至 35 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meeting DSM-IV criteria for schizophrenia, schizophreniform or schizo-affective psychosis as assessed by the research team
- •In an episode as defined by the presence of positive symptoms measured by Positive and Negative Syndrome Scale with a score higher than two in items 1,2,3 or 6 in the Positive scale
- •In contact with early intervention community or in-patient service
- •Within 5 years of first diagnosis
- •Intelligence quotient (IQ) greater than 70
- •Participants and their partners must be willing to use effective birth control throughout the study and seven days after stopping trial medication. Females should have a negative pregnancy test
- •Able to understand and willing to give written informed consent
- •Fluent in English
排除标准
- •Current substance misuse diagnosis that in the opinion of the investigator may interfere with the study
- •Patients who, in the investigator's judgement pose a current serious suicidal or violence risk
- •Use of tetracycline antibiotics within 2 months of the randomisation visit or history of sensitivity or intolerance for this type of antibiotics
- •History of Systemic Lupus Erythematosis (SLE) or a history of SLE in a first-degree relative
- •Use of any investigational drug within a month of randomisation visit
- •Relevant current or past hematologic, hepatic, renal, neurological or other medical disorder in the opinion of the principal investigator (PI) or the responsible medical officer (RMO) may interfere with the trial
- •Taking medical treatments that could seriously interact with minocycline as described in the summary of product characteristics (SPC) and judged by the PI or the RMO
- •Clinically significant deviation from the reference range in clinical laboratory test results as judged by the investigator
- •Previous randomisation in the present study
- •Pregnant or breastfeeding
- •Meeting MRI exclusion criteria as defined by local scanning centres
研究组 & 干预措施
Minocycline
Participants will receive capsules containing 100mg of minocycline (modified release), two per day for the first two weeks of the trial and then three per day for the remainder of the 12 month treatment period in addition to antipsychotic drug treatment and other interventions by the responsibel medical officer.
干预措施: Minocycline (Drug)
Placebo
Participants will receive placebo capsules entirely matching minocycline, two per day for the first two weeks of the trial and then three per day for the reminder of the 12 month treatment period in addition to antipsychotic drug treatment and other interventions by the responsibel medical officer.
干预措施: Placebo (Drug)
结局指标
主要结局
Severity of negative symptoms of psychosis
时间窗: twelve months
Measured by Negative symptoms scale in the Positive and Negative Syndrome Scale
次要结局
- Change in body weight(Twelve months)
- Positive symptoms of psychosis(twelve months)
- General social and psychological functioning(twelve months)
- Social and Occupational functioning(12 months)
- Intelligence(twelve months)
- Anti-psychotic medication dose(twelve months)
- Verbal learning(12 months)
研究者
Bill Deakin
Professor of Psychiatry and Director of Neuroscience Research in the Division of Psychiatry
University of Manchester