Muscle properties in children with cerebral palsy undergoing orthopaedic surgical intervention to improve gait - Muscle properties in cerebral palsy after surgery to improve gait

Vrije Universiteit Medisch Centrum0 个研究点目标入组 86 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•1. Clinical diagnosis of spastic cerebral palsy
•2. Indication for surgical lengthening of thigh and/or calf muscles / or injections with Botuline A-Toxine in combination with a bony procedure targeting the increase of knee extension
•3. Gross Motor Function Classification System Class I-III (ability to walk with or without aids)
•4. Age: 6-20 years ;Patients for reliability-study
•1. Clinical diagnosis of spastic cerebral palsy
•2. Gross Motor Function Classification System Class I-III (ability to walk with or without aids)
•3. Age: 8-16 years
•Control group (2 groups, for detailed description see protocol page 12/13):
•1. Typically developing and healthy persons
•2. Age: 6-20 years
•1. Planned surgical intervention during which harvesting of a control biopsy is possible without an additional skin incision or prolonged anaesthesia
•2. Age: 6-40 years;Typically developing children for reliability study
•1. Age: 6-40 years

•1. Treatment of muscles, which are indicated for surgical procedures, with Botuline A -Toxine within three months before surgery.
•2. A pre-surgical treatment with selective dorsal rhizotomy, intrathecal baclofen pump or prior surgery of treated muscle
•3. Major disease or accident one year prior to measurements or a disturbed normal activity level of the child for more than three weeks in the last half year
•4. 24-hour casting for more than two weeks, that includes the treated muscle three month prior to surgery
•5. Additional neuromuscular, orthopaedic, inflammatory or systemic diseases which can influence walking ability or muscle properties
•6. Medication that influences neuromuscular properties three month prior to surgery
•7. Parents/guardians or child do not cooperate well enough to take part in the project;Patients for reliability-study & 1st Control group:
•Same as 1., 3. and 7. for patients;2nd control group:
•Sames as for patient

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