LYmphangiogenesis FacTors in Heart Failure States (LYFT-HF Study)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Vascular Endothelial Growth Factor (VEGF) Levels
研究概览
简要总结
Heart failure often causes fluid to accumulate in the body, leading to congestion and swelling. However, some people who have had heart failure for a long time seem to have very little congestion or swelling, even when the heart failure is poorly treated. The investigators think that this is because lymphatic vessels are able to grow and remove fluid to prevent congestion. The investigators do not know how lymphatic vessels grow. This study will investigate the blood levels of various proteins to try to figure out how the lymph vessels of people with long-standing heart failure might grow.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergoing clinically indicated right heart catheterization.
排除标准
- •Unable to provide consent.
- •Use of medications which may alter lymphangiogenesis factor expression within 365 days
- •Thalidomide, lenalidomide, pomalidomide
- •Bevacizumab
- •Any cytotoxic chemotherapy agents
- •Any potentially pregnant patient (based on age and gender) undergoes Beta Human chorionic gonadotropin testing as standard of care prior to any right heart catheterization.
- •Active cancer within 365 days
- •Diagnosis of familial or secondary lymphedema
- •Treatment of active bacterial infection within 7 days
- •Active inflammatory rheumatologic disease requiring anti-inflammatory therapy administration within 60 days
- •Conditions
- •Systemic lupus erythematosus
- •Rheumatoid arthritis
- •Scleroderma
- •Inflammatory myositis
- •Vasculitis
- •Behcet's disease
结局指标
主要结局
Vascular Endothelial Growth Factor (VEGF) Levels
时间窗: At time of right heart catheterization
VEGF levels in systemic venous, pulmonary arterial, and pulmonary venous samples in participants with left heart failure versus those without left heart failure.
次要结局
- Lymphangiogenesis and Heart failure severity(At time of right heart catheterization)
- Lymphangiogenesis and 6 minute hall walk(At time of right heart catheterization)
- Lymphangiogenesis factors and Pulmonary Capillary Wedge Pressure (PCWP)(At time of right heart catheterization)