Rehabilitation of Patients with Rheumatoid Arthritis (RA): Changes in Muscle, Functional and Biochemical Parameters
Completed
- Conditions
- Arthritis (rheumatoid)Musculoskeletal DiseasesOther rheumatoid arthritis
- Registration Number
- ISRCTN87704142
- Lead Sponsor
- Record Provided by the NHS R&D 'Time-Limited' National Programme Register - Department of Health (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 133
Inclusion Criteria
Patients with knee and elbow rheumatoid arthritis.
1. Knee study: 133 participants were recruited to the cross-sectional study, 108 RA patients and 25 healthy participants. 93 patients were recruited to the rehabilitation trial.
2. Elbow study: 21 participants were recruited to the cross-sectional study, 12 patients with RA and 9 healthy participants. These 12 patients participated in the rehabilitation study.
Exclusion Criteria
Does not match inclusion criteria
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Knee Study: Isometric quadriceps strength<br>2. Elbow Study: Elbow flexor strength
- Secondary Outcome Measures
Name Time Method 1. Knee Study: <br>1.1. Voluntary quadriceps activation<br>1.2. Knee joint position sense<br>1.3. 4 common activities of daily living<br>1.4. Health Assessment Questionnaire (HAQ)<br>1.5. Disease Repercussion Profile <br>1.6. Clinical measures if disease activity in RA <br>1.7. Serum concentrations of IL-1, IL-6, TNF-alpha<br><br>2. Elbow Study:<br>2.1. Voluntary flexor activation<br>2.2. Elbow joint position sense<br>2.3. HAQ<br>2.4. Arthritis Impact Measurement Scale-2 <br>2.5. Clinical measures of disease activity