The effect of Artichoke Leaf Extract in the patients with Non Alcoholic Steatohepatitis (NASH).
- Conditions
- non alcoholic steatohepatitis.Fatty (change of) liver, not elsewhere classified
- Registration Number
- IRCT2014070218321N1
- Lead Sponsor
- Qazvin University of Medical Sciences, Faculty of Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Abnormal serum transaminases = 30 U/L ; Fatty liver in ultrasonography; At least one of the following, FBS greater than 100 mg/dL or a previous diagnosis of type II diabetes,obesity ( Body mass index of 30 or higher ),Blood pressure greater than 130/85 ,Triglyceride-levels greater than 150 mg/dl ,HDL-cholesterol lower than 40 mg/dl (men) and 50 mg/dl (women) ,Total cholesterol greater than 200 mg/dl.
Exclusion criteria:Daily alcohol consumption;Type I diabetes;Concomitant liver diseases,Presence of HCV antibody or HBs antigen, auto-immune hepatitis, hemochromatosis, Wilson’s disease, alpha1 anti-trypsin deficiency, Biliary obstruction;Use of livergol,Vit E, Vit C,UDCA,Heptotoxic Drug;Treatment with a drug known to induce NASH (amiodarone,calcium channel blocker, tamoxifen), and oral anticoagulation;Decompensated cirrhosis;Serious disease limiting life expectancy;Pregnancy and lactation;people who are Allergy sensitive to the Asteraceae/Compositae family.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Alanine aminotransferase (ALT). Timepoint: before and after intervention. Method of measurement: IU/Lit.;Aspartate aminotransferas (AST). Timepoint: before and after intervention. Method of measurement: IU/Lit.
- Secondary Outcome Measures
Name Time Method Total cholestrol. Timepoint: before and after the intervention. Method of measurement: Mg/dL.;LDL-C. Timepoint: before and after the intervention. Method of measurement: Mg/dL.;HDL-C. Timepoint: before and after the intervention. Method of measurement: Mg/dL.;Triglycerid. Timepoint: before and after the intervention. Method of measurement: Mg/dL.;Fasting blood sugar. Timepoint: before and after the intervention. Method of measurement: Mg/dL.