Management of cryptorchidism in congenital hypogonadotropic hypogonadism(Hormone therapy for undescended testes)
- Conditions
- Health Condition 1: E236- Other disorders of pituitary gland
- Registration Number
- CTRI/2020/07/026754
- Lead Sponsor
- Department of Endocrinology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 6
Male Patients with CHH with cryptorchidism, unilateral or bilateral.
The diagnosis of CHH was based on the following criteria:
(1)Clinical Phenotype- Unilateral or bilateral cryptorchidism with micropenis since birth
AND
(2) Evidence of CHH based on 1 of the following criteria
a) Age > 14 years with absence of secondary sexual characters with low or normal gonadotropins along with low Inhibin B and Testosterone for age
b) clinical history of anosmia/hyposmia and/or MRI Pituitary showing hypoplasia / aplasia of olfactory bulbs and sulci
c) Genetic analysis conducive with CHH
d) Syndromic etiology with CHH as a component
AND
3) Normal levels of other pituitary hormones
4) Absence of any structural lesions on imaging (MRI) of brain
Idiopathic cryptorchidism or cryptorchidism of any etiology other than CHH.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Testicular volume and descent,Penile length, <br/ ><br>Hormonal response: Inhibin-B,Testosterone <br/ ><br>Spermatogenesis and fertilityTimepoint: 3 and 6 months
- Secondary Outcome Measures
Name Time Method Spermatogenesis and fertilityTimepoint: 12 months