The Hasselt APPendicitis Immunology and Environmental Cohort STudy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 308
- 试验地点
- 2
- 主要终点
- Genetic susceptibility
研究概览
简要总结
The Hasselt Appendicitis Immunology and Environmental Study (HAPPIEST) aims at characterizing factors that influence the development and severity of acute appendicitis. In a cohort of 300 patients and 300 controls, environmental factors as well as genetic make-up of the innate immune system, focusing mainly on pattern recognition, will be analyzed in order to gain insight in their relative importance in the pathology of appendicitis. Furthermore, populations of micro-organisms present in the gut of patients will be characterized, and the interaction between relevant micro-organisms and the innate immune system will be analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 85 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Acute appendicitis
- •Appendectomy within 7 days after onset of symptoms
- •Signed informed consent
排除标准
- •Appendectomy 7 days or more after onset of symptoms
- •Participation in any clinical investigational drug study within 4 weeks of screening
- •Severe, life-threatening disease with a life expectancy of less than 2 months.
结局指标
主要结局
Genetic susceptibility
时间窗: Within 2 years after inclusion of the last patient
DNA sample collected at inclusion
次要结局
- Environmental factors(Within 6 months after inclusion of the last patient)
- Immunology composite outcome(within 4 years)
研究者
prof. dr. Inge Gyssens
Prof. Dr.
Hasselt University