Postgenome-based Systemic Discovery of Strong Biomarkers Predict Gastric Cancer Chemotherapy Response
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 800
- 试验地点
- 1
- 主要终点
- Discovery of predicting bio-markers for gastric cancer chemotherapy response
研究概览
简要总结
-
discovery and validation of biomarker predicting gastric cancer chemotherapy response
-
Analysis for expression level of mRNA using Next generation sequencing in gastric cancer tissue by chemotherapy response
-
Analysis for expression level of miRNA using Next generation sequencing in gastric cancer tissue and blood by chemotherapy response
-
Validation of mRNA and miRNA using qRT-PCR in multiple independent cohort
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Biological biomarkers-clinical factor combined prediction model of gastric cancer chemotherapy response
详细描述
-
discovery and validation of biomarker predicting gastric cancer chemotherapy response
-
Analysis for expression level of mRNA in fresh frozen gastric cancer tissue by chemotherapy response (A) method of mRNA expression measurement: RNA sequencing (B) study group Palliative chemotherapy (inoperable patients)
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institutional primary Chemotherapy regimen (XP or Xelox)
- response group
- progression group
Post-OP adjuvant chemotherapy
- institutional primary Chemotherapy regimen
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •new gastric cancer patients who has scheduled to start 1st cycle of chemotherapy
- •patients who agreed this study and voluntarily assigned the informed consents.
排除标准
- •patients who refused the study.
- •patients who have other cancers
- •heavy alcoholics
研究组 & 干预措施
responder in palliative chemotherapy
After initial chemotherapy, responder (complete remission, partial remission)
干预措施: Chemotherapy (Drug)
non-responder in palliative chemotherapy
After initial chemotherapy, disease progression
干预措施: Chemotherapy (Drug)
responder in adjuvant chemotherapy
complete cure and no recurrence at least 1 year after treatment
干预措施: Chemotherapy (Drug)
non-responder in adjuvant chemotherapy
non-complete cure or recurrence within 1 year after treatment
干预措施: Chemotherapy (Drug)
结局指标
主要结局
Discovery of predicting bio-markers for gastric cancer chemotherapy response
时间窗: up to 36 months
Discovery of predicting bio-markers for gastric cancer chemotherapy response using next generation sequencing and qRT-PCR
次要结局
- Combination prediction model for palliative chemotherapy response in gastric cancer(up to 3 years)
- Combination prediction model for adjuvant chemotherapy response in gastric cancer(up to 5 years)
研究者
Su Youn Nam
Professor
Kyungpook National University Chilgok Hospital