Effects of multi-strain probiotic and prebiotic supplementation on body composition, biochemical blood profiles, and gut microbiomes in overweight and obese subjects
Phase 3
Completed
- Conditions
- Obesity, overweight
- Registration Number
- TCTR20220828002
- Lead Sponsor
- ATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 63
Inclusion Criteria
Overweight and obesity (BMI of 23-30 kg/m2)
Exclusion Criteria
Subjects with hypertension, type 2 diabetes, used medicine of previous or current treatment for gastrointestinal diseases, chronic diseases, thyroid abnormality or immune-compromising disease, hepatitis, cancer, transplant patient, used probiotic supplement 2 weeks before screening, used antibiotic medicine before 4 weeks, used medicine affecting bodyweight, energy expenditure, or glucose for last 3 months, used vitamin and mineral supplement within 6 months before screening, current smoker, alcohol drinking, pregnant or lactation were excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method body composition 0, 6 wk, 12 wk BMI, Weight, Waist circumference, %fat
- Secondary Outcome Measures
Name Time Method gut microbiomes 0, 12 wk Sequencing bacteria analysis,Biochemical assessment 0,6,12 wk Plasma glucose, cholesterol, triglyceride, HDL, LDL, ALT, AST, B