Interference With Cognitive Control by Transcranial Direct Current Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Correctness and reaction time of response
研究概览
简要总结
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of a decrease of dlPFC activity in healthy subjects by cathodal transcranial direct current stimulation (tDCS) on cognitive control.
In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session of cathodal tDCS to the left dlPFC on cognitive control in healthy subjects. To assess the cognitive control the investigators use a delayed response working memory task (DWM)and an arithmetic inhibition task (AIT) with pictures of varying valence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •informed consent
排除标准
- •psychiatric or neurological disorders seizures cardiac pacemakers
研究组 & 干预措施
Cathodal transcranial direct current stimulation
干预措施: Cathodal transcranial direct current stimulation (tDCS) (Device)
Sham transcranial direct current stimulation
干预措施: Sham transcranial direct current stimulation (Device)
结局指标
主要结局
Correctness and reaction time of response
时间窗: Within 30 min starting 5 min after the initiation of stimulation
Correctness is defined as the percentage of correct responses in the DWM and AIT
次要结局
未报告次要终点
研究者
Christian Plewnia, MD
Professor
University Hospital Tuebingen