A clinical trial To Compare The Effect Of Volume Guaranteed Ventilation Versus Pressure Controlled Ventilation In Preterm Infants With Respiratory Distress Syndrome

Not yet recruiting

• Conditions: Other specified respiratory disorders,

• Registration Number: CTRI/2022/06/043015
• Lead Sponsor: Dr Ghanshyam Saini

Brief Summary

Mechanical ventilation is primarily used because an infant is failing to breathe adequately, leading to CO2 retention. CO2 removal is determined by tidal volume (VT) and respiratory or ventilator rate. Volume ventilation (VTV) strategies aim to deliver a consistent VT. Advances in neonatal intensive care have resulted in increasing survival of very preterm and extremely preterm infants. Modern neonatal ventilation modes can target a set tidal volume as an alternative to traditional pressureâ€limited ventilation (PLV) using a fixed inflation pressure. Volumeâ€guaranteed ventilation aims to produce a more stable tidal volume in order to reduce lung damage and stabilize the partial pressure of carbon dioxide (pCO2).

The VG mode also facilitates automatic weaning and as the patient lung compliance improves, the peak inspiratory pressure is automatically reduced to attain the set tidal volume

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-03-06
• Study Start: 2022-05-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 116

Inclusion Criteria

• Neonates born preterm between 27-34 weeks 2.
• Either gender.
• Neonates developing RDS within first 7 days of life 4.

Exclusion Criteria

• Neonates with: a.
• Life threatening congenital malformations b.
• Air Leak Syndromes c.
• Birth Asphyxia d.
• Meconium Aspiration e.
• Severe IVH 2.
• Parents not giving valid consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total Duration of Mechanical Ventilation	Total Duration of Mechanical Ventilation during hospital stay

Secondary Outcome Measures

Name	Time	Method
1.Failure of primary treatment i.e clinical decision to change the mode of ventilation	2.incidence of the complications, such as air leaks, intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and peri-ventricular leukomalacia(PVL) etc will also be studied.

Trial Locations

Locations (1)

GMC Jammu; 🇮🇳 JAMMU, & KASHMIR, India

GMC Jammu

🇮🇳JAMMU, & KASHMIR, India

Dr Ghanshyam Saini

Principal investigator

9419193571

gs_saini63@yahoo.com