Modified INSURE vs INSURE in Preterm Infants With Respiratory Distress Syndrome: A Randomized Controlled Trials
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Modified INSURE Technique
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- intubation rate
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
In preterm infants with respiratory distress syndrome, mechanical ventilation is related to increased risk of death and complications. Surfactant is an important methods to reduce mortality and intubation rates. INSURE technique is a standard method to administrate surfactant. However, several preterm infants need two or more surfactant, and therefore one more intubation is needed. How to reduce the times of intubation is an challenges for neonatologists.
Detailed Description
INSURE technique meas surfactant administration through intubation-surfactant-extubation. And noninvasive ventilation is immediately used after surfactant. The differences of modified INSURE compared with INSURE is intubation-surfactant-X-ray relieved-extubation. Extubation and noninvasive ventilation is used after the X-ray relieving.
Investigators
Fang Wu
Principal Investigator
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Eligibility Criteria
Inclusion Criteria
- •All preterm infants with respiratory distress syndrome
Exclusion Criteria
- •congenital abnormalities or refuse the trials
Outcomes
Primary Outcomes
intubation rate
Time Frame: 100-days