Comparison Of The Efficacy Of Combination Of TAM Formula Versus Kligman Formula For Melasma At Tertiary Care Hospital,Karachi.
试验速览
- 阶段
- 2 期
- 入组人数
- 122
- 试验地点
- 1
- 主要终点
- EFFICACY OF COMBINATION OF TAM FORMULA VERSUS KLIGMAN FORMULA IN TREATMENT OF MELASMA
研究概览
简要总结
This study would offer the participants about the knowledge of these formula in the treatment of melasma and help the investigators in incorporating and updating the management protocols in medical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients between 25-65 years of age, either gender having melasma for over one month will be included in the study
排除标准
- •Pregnancy, breastfeeding, taking birth control pills or plans to become pregnant during the study
- •History of cutaneous photosensitization, porphyria, and hypersensitivity to porphyrins or photodermatosis
- •History of skin pathology or condition that could interfere with the evaluation or requires the use of interfering topical or systemic therapy
- •History of uncorrected coagulation defect or is currently using anti-coagulation medication (including but not limited to heavy aspirin therapy)
- •History of sensitivity to hydroquinone or Retin-A
- •History of evidence of a compromised immune system or hepatitis
研究组 & 干预措施
Group B Kligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%)
干预措施: Kligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%) (Combination Product)
Group A TAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C)
干预措施: TAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C) (Combination Product)
结局指标
主要结局
EFFICACY OF COMBINATION OF TAM FORMULA VERSUS KLIGMAN FORMULA IN TREATMENT OF MELASMA
时间窗: Efficacy will be assesed upto 2 months.
Efficacy will be assessed by using Modified MASI(Melasma Area and Severity Index)In MASI scoring the "area of involvement" is calculated from 0 to 6 while the intensity and homogeneity of pigmentation are scored from 0 to 4 only. (Melasma Area Severity Index)
次要结局
未报告次要终点
研究者
Dr Khadijah Asadullah
Principal Investigator
Jinnah Postgraduate Medical Centre