Clinical study of modified Guipi decoction in improving cognitive function of children with cblC methylmalonic aciduria
Phase 1
Recruiting
- Conditions
- Methylmalonic aciduria
- Registration Number
- ITMCTR2100005327
- Lead Sponsor
- The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
1.The diagnosis of MMA was consistent with cblC type of deficiency of both heart and spleen;
2.With complications of cognitive impairment, (WISC-IV) scale score IQ below 90;
3.The age ranged from 1 to 6 years old;
4.The legal guardian of the child signed the informed consent and was willing to accept traditional Chinese medicine treatment and clinical investigation.
Exclusion Criteria
1.Patients with severe visual impairment, hearing impairment and cardiovascular and cerebrovascular diseases were present;
2.Patients with other diseases that seriously affect cognitive function, such as hypothyroidism and hydrocephalus;
3.Patients with severe infection, abnormal liver and kidney function and metabolic disorder.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Wechsler Intelligence Scale Fourth Edition (WISC-IV);
- Secondary Outcome Measures
Name Time Method Infant-Social life ability scale for infant junior high school students (S-M);