Influence of Extracorporeal Circulation During Cardiac Surgery on the Development of Postoperative Thrombotic Thrombocytopenic Purpura (TTP)

• Conditions: Cardiac Surgery

• Registration Number: NCT01300117
• Lead Sponsor: Johann Wolfgang Goethe University Hospital

Brief Summary

The purpose of this study is to determine whether extracorporeal circulation during cardiac surgery has an influence on ADAMTS13-Activity.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-10
• Study First Submitted: 2011-02-18
• Study First Submitted QC: 2011-02-18
• Study First Posted: 2011-02-21
• Status Verified: 2011-12
• Last Update Submitted: 2011-12-28
• Last Update Posted: 2011-12-29

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• cardiac surgery with or without (OPCAB) the use of extracorporeal circulation
• patient agrees

Exclusion Criteria

• no agreement
• known TTP in medical history

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in ADAMTS13-Activity over time	during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery

Secondary Outcome Measures

Name	Time	Method
Change in ADAMTS13-Antibody over time	during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery
Change in Platelet count over time	during surgery (at 1and 2 hours after beginning) and within the first 6 days after surgery
time duration of extracorporeal circulation during surgery	during surgery
Amount of intraoperative given fluid replacement	during surgery
Amount of given blood products (red blood cells)	24 hours

Trial Locations

Locations (1)

Johann Wolfgang Goethe University Hospital; 🇩🇪 Frankfurt, Hessen, Germany