Exertional breathlessness in pulmonary arterial hypertensio
- Conditions
- Pulmonary arterial hypertensionCardiovascular - Other cardiovascular diseasesRespiratory - Other respiratory disorders / diseasesCardiovascular - Hypertension
- Registration Number
- ACTRN12622000493741
- Lead Sponsor
- niversity of Auckland
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 28
•Patients with Group 1 PAH as per 6th World Symposium on Pulmonary Hypertension
•Exertional dyspnoea (WHO functional class II and III)
•Control participants free from PAH, age and sex-matched with no known health conditions
•Men and women
•Aged 18 years or over
•Group 2, 3, 4, 5 pulmonary hypertension
•Six minute walk distance < 300m
•Dyspnoea at rest (WHO functional class IV)
•Significant left ventricular dysfunction (Left ventricular ejection fraction <40% or significant diastolic dysfunction)
•Obstructive or restrictive lung disease
oPulmonary fibrosis or emphysema on chest radiograph or computed tomography scan
oTotal lung capacity <80% of predicted
oForced expiratory volume in first second of expiration/ forced vital capacity <70%
oCurrently taking regular inhaled therapy for airways disease
•Serious co-morbidities that may contribute to dyspnoea and/or reduce exercise capacity including:
oSevere cardiac disease (e.g., heart failure, coronary artery disease)
oSevere respiratory disease other than PAH (e.g., chronic obstructive pulmonary disease, interstitial lung disease)
oSevere obesity (Body mass index > 35 kg/m2)
oSevere orthopaedic impairment or rheumatologic/ connective tissue disease
oSignificant neurological disease
oSignificant renal or liver disease
oInfection or pyrexial illness
oUncontrolled thyroid disorders
oCurrent active treatment for cancer
•Presence of any contraindications to cardiopulmonary exercise testing
oUnstable angina or recent acute myocardial infarction
oUncontrolled arrhythmias causing symptoms or haemodynamic compromise
oSymptomatic severe aortic stenosis
oOxygen saturation <85% at rest on room air
oUncontrolled heart failure
oUncontrolled asthma
oUncontrolled thyroid disorders
oMental impairment leading to inability to cooperate
oLong-term oxygen therapy
•Current pregnancy
•Current users of recreational drugs
•Current abusers of alcohol
•Inability to fully or appropriately provide consent (e.g., language issue, reading capability)
•Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method