Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke

Recruiting

• Conditions: Transient Ischemic Attack; Coagulation Disorder; Stroke, Ischemic

• Registration Number: NCT05645081
• Lead Sponsor: Cwm Taf University Health Board (NHS)

Brief Summary

Annually 100,000 strokes occur, placing stroke as the largest cause of disability in the UK. 90% of strokes are preventable, leading to national focus on programmes including "The National Stroke Programme" to act on preventing, treating, and improving post-stroke care. Importantly, over 25% of ischaemic stroke sufferers have previously had a Transient Ischaemic Attack (TIA), which presents the biggest concern for TIA patients. There are no measures which reliably identify TIA patients most likely to suffer a stroke. Novel biomarkers for predicting stroke are key to addressing this problem. The PREDICT-EV study aims to screen 300 TIA patients and follow them over 12-months. The investigators will determine if a novel biomarker we've identified to increase thrombotic risk (endothelial derived extracellular vesicles) and the resulting increased prothrombin time is associated with patients at highest risk of stroke.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-01
• Study First Submitted: 2022-12-01
• Study First Submitted QC: 2022-12-08
• Study First Posted: 2022-12-09
• Status Verified: 2024-02
• Last Update Submitted: 2024-08-19
• Last Update Posted: 2024-08-20
• Primary Completion: 2026-09-01
• Study Completion: 2027-09-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 360

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in the endothelial derived extracellular vesicle population	3 years
Change in patient Prothrombin time	3 years

Trial Locations

Locations (1)

Prince Charles Hospital; 🇬🇧 Merthyr Tydfil, United Kingdom