A Phase IIR/III Trial of Standard of Care Therapy With or Without Stereotactic Body Radiotherapy (SBRT) and/or Surgical Ablation for Newly Oligometastatic Breast Cancer
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- NRG Oncology
- 入组人数
- 129
- 试验地点
- 295
- 主要终点
- Progression-free Survival (Phase II)
研究概览
简要总结
This randomized phase II/III trial studies how well standard of care therapy with stereotactic radiosurgery and/or surgery works and compares it to standard of care therapy alone in treating patients with breast cancer that has spread to one or two locations in the body (limited metastatic) that are previously untreated. Standard of care therapy comprising chemotherapy, hormonal therapy, biological therapy, and others may help stop the spread of tumor cells. Radiation therapy and/or surgery is usually only given with standard of care therapy to relieve pain; however, in patients with limited metastatic breast cancer, stereotactic radiosurgery, also known as stereotactic body radiation therapy, may be able to send x-rays directly to the tumor and cause less damage to normal tissue and surgery may be able to effectively remove the metastatic tumor cells. It is not yet known whether standard of care therapy is more effective with stereotactic radiosurgery and/or surgery in treating limited metastatic breast cancer.
详细描述
PRIMARY OBJECTIVES:
I. Phase II: To determine whether ablation [through stereotactic body radiation therapy (SBRT) (stereotactic radiosurgery) and/or surgical resection of all known metastases] in oligometastatic breast cancer patients provides a sufficient signal for improved progression-free survival (PFS) to warrant full accrual to the Phase III portion of the trial.
II. Phase III: To determine whether ablation (through SBRT and/or surgical resection of all known metastases) in oligometastatic breast cancer patients significantly improves overall survival (OS).
SECONDARY OBJECTIVES:
I. To evaluate treated metastasis control according to tumor receptor status [estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2)], use of chemotherapy, surgery versus (vs.) ablative therapy, and number of metastases.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •A patient cannot be considered eligible for this study unless all of the following conditions are met.
- •Pathologically confirmed metastatic breast cancer
- •Known estrogen, progesterone, and HER2 status of either primary tumor or metastasis;
- •Note: estrogen, progesterone and HER2 status of metastasis preferred for stratification
- •Number of allowable metastases:
- •=< 4 metastases seen on standard imaging within 60 days prior to registration when all metastatic disease is located within the following sites:
- •Peripheral lung
- •Osseous (bone)
- •Central lung
- •Abdominal-pelvic metastases (lymph node/adrenal gland)
- •Mediastinal/cervical lymph node
- •All known disease amenable to metastasis-directed therapy with either SBRT or resection
- •Note: Symptomatic bone metastasis are allowed if ablative therapy can be delivered
- •Note: Sites for possible surgical excision include lung, liver, adrenal gland, bone, small intestine, large intestine, ovary, and amenable nodal disease sites
- •Note: Surgical stabilization is allowed for a metastasis if it is followed by conventionally fractionated external beam radiotherapy
- •Maximum diameter of individual metastasis in any dimension =< 5 cm
- •There are no restrictions on distance between the metastases
- •Patients must be registered within 365 days of the initial metastatic breast cancer diagnosis; first-line standard systemic therapy (chemotherapy, anti-endocrine therapy, anti-HER2, or other standard targeted therapy) for metastatic breast cancer must be given or planned to be given; if given before study entry, it cannot have exceeded a duration of 12 months at the time of registration (Note: sequencing of ablative therapy [surgery or SBRT] relative to systemic therapy, for patients randomized to Arm 2, is at the discretion of the treating physician)
- •The primary tumor site must be controlled prior to registration
- •For those who present with synchronous primary and oligometastatic disease, primary must be controlled prior to registration
- •The definition of control is definitive surgery by excision or mastectomy (+/- radiotherapy) per institution preference For those who present with local recurrence and oligometastatic disease, local recurrence must be controlled prior to registration
- •The definition of control is definitive surgery by excision or mastectomy (+/- radiotherapy) per institution preference
- •Appropriate stage for study entry based on the following diagnostic workup:
- •History/physical examination within 60 days prior to registration
- •Clinical grade computed tomography (CT) scans of the chest, abdomen, and pelvis with radionuclide bone scan OR whole body positron emission tomography (PET)/CT within 60 days prior to study registration
- •Zubrod performance status =< 2 within 60 days prior to registration
- •Blood cell count (CBC)/differential obtained within 60 days prior to registration on study
- •Absolute neutrophil count (ANC) >= 500 cells/mm^3
- •Platelets >= 50,000 cells/mm^3
- •Hemoglobin >= 8.0 g/dl (note: the use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 8.0 g/dl is acceptable)
- •For females of child-bearing potential, negative serum or urine pregnancy test within 14 days prior to study registration
- •The patient or a legally authorized representative must provide study-specific informed consent prior to study entry
排除标准
- •Patients with any of the following conditions are NOT eligible for this study.
- •Pathologic evidence of active primary disease or local/regional breast tumor recurrence at the time of registration;
- •Co-existing or prior invasive malignancy (except non-melanomatous skin cancer), unless disease free for a minimum of 3 years; previous RT dose, date, fraction size, must be reported
- •Metastases with indistinct borders making targeting not feasible
- •Note: A potential issue with bone metastases is that they often are not discrete; since many patients on this protocol will have bone metastases, this will be an important issue; theoretically, Houndsfield units might provide an appropriate measure; however, a sclerotic lesion against dense cortical bone will not have a sharp demarcation based on Houndsfield units (HU); therefore, we acknowledge that such determinations will pose a challenge and thus the physician's judgment will be required
- •Prior palliative radiation treatment for metastatic disease to be treated on the protocol (including radiopharmaceuticals)
- •Metastases located within 3 cm of the previously irradiated structures:
- •Spinal cord previously irradiated to > 40 Gy (delivered in =< 3 Gy/fraction)
- •Brachial plexus previously irradiated to > 50 Gy (delivered in =< 3 Gy/fraction)
- •Small intestine, large intestine, or stomach previously irradiated to > 45 Gy (delivered in =< 3 Gy/fraction)
- •Brainstem previously irradiated to > 50 Gy (delivered in =< 3 Gy/fraction)
- •Whole lung previously irradiated with prior percent volume receiving greater than or equal to 20 Gy (V20Gy)> 30% (delivered in =< 3 Gy/fraction)
- •Primary tumor irradiated with SBRT
- •Metastasis irradiated with SBRT
- •Brain metastases
- •Exudative, bloody, or cytological proven malignant effusions
- •Severe, active co-morbidity defined as follows:
- •Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
- •Transmural myocardial infarction within the last 6 months
- •Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
- •Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
- •Pregnancy; lactating females must cease expression of milk prior to signing consent to be eligible
- •Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a cluster of differentiation 4 (CD4) count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol
研究组 & 干预措施
Standard of Care + Ablation
Standard of care systemic therapy plus ablation of all metastases by stereotactic body radiotherapy or surgery at the discretion of the treating physician.
干预措施: Surgery (Procedure)
Standard of Care (SOC)
Standard of care systemic therapy at the discretion of the treating physician.
Standard of Care + Ablation
Standard of care systemic therapy plus ablation of all metastases by stereotactic body radiotherapy or surgery at the discretion of the treating physician.
干预措施: Stereotactic Body Radiotherapy (Radiation)
结局指标
主要结局
Progression-free Survival (Phase II)
时间窗: From randomization to last follow-up. Follow-up schedule: 3 mos after randomization and every 3 months to 24 months, then every six months to five years, then annually. Maximum follow-up at time of analysis was 63 months.
Progression (failure) is defined as any of the following: progression of metastases, new metastases, or death. Progression-free survival (PFS) time is defined as time from randomization to the date of first progression, death, or last contact when participant had a documented clinical assessment (censored). PFS rates are estimated using the Kaplan-Meier method. The protocol specifies that the distributions of failure times be compared between the arms, which is reported in the statistical analysis results. Median PFS is provided.
Overall Survival (Phase III)
时间窗: From randomization to last follow-up. Follow-up schedule: 3 mos after randomization and every 3 months to 24 months and then annually. Maximum follow-up at time of analysis was 63 months.
Overall survival time is defined as time from randomization to the date of death from any cause or last known follow-up (censored).
次要结局
- Percentage of Participants With New Metastases(From randomization to last follow-up. Follow-up schedule: 3 months after randomization, every 3 months up to 24 months, every six months up to five years, then annually. Maximum follow-up at time of analysis was 63 months.Two-year rates are provided here.)
- Percentage of Participants With Treated Metastasis Progression on the SOC + Ablation Arm(From randomization to last follow-up. Follow-up schedule: 3 months after randomization, every 3 months up to 24 months, every six months up to five years, then annually. Maximum follow-up at time of analysis was 63 months. Two-year rates are provide here.)
- Number of Patients by Highest Grade Adverse Event Reported(From randomization to last follow-up. Follow-up schedule: Arm 1: 3 mos. after randomization / Arm 2: weekly during SBRT and the last day of SBRT; both arms: then every 3 mos. to 24 mos., then annually. Maximum follow-up at time of analysis was 63 months.)
- Progression-free Survival in the Presence or Absence of Circulating Tumor Cells (CTCs)(From randomization to last follow-up. Follow-up schedule: 3 months after randomization, every 3 months up to 24 months, every six months up to five years, then annually. Maximum follow-up at time of analysis was 63 months.Two-year rates are provided here.)