Image guided intensity modulated External beam radiotherapy and MRI based adaptive Brachytherapy in locally advanced cervical cancer (EMBRACE II) - EMBRACE-II

Tata Memorial Hospital0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1.Cancer of the uterine cervix considered suitable for curative treatment with definite radio-chemo therapy including MRI guided BT.
•2. Positive biopsy showing squamous cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix.
•3.Staging according to FIGO and TNM guidelines.(Stage IB,IIA,IIB,IIIA,IIIB and IVA)
•4. MRI of pelvis at diagnosis is performed.
•5. MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed.
•6. MRI with applicator in place at time of (first) BT will be performed.
•7. Para-aortic metastatic nodes below L1-L2 are allowed.
•8. Patient informed consent.

•1. Other primary malignancies except carcinoma in situ of the cervix and basal cell carcinoma of the skin.
•2. Small cell neuroendocrine cancer, melanoma and other rare cancer in the cervix.
•3. Metastatic disease above and beyond the retroperitoneal para-aortic L1-L2 interspace.
•4. Previous pelvic or abdominal radiotherapy.
•5. Previous total or partial hysterectomy.
•6. Combination of preoperative radiotherapy with surgery.
•7. Patient receiving BT only.
•8. Patient receiving EBRT only.
•9. Patients receiving neo-adjuvant chemotherapy or other forms of antineoplastic treatment apart from weekly concomitant cisplatin (40mg/2).However, adjuvant chemotherapy in the form of 4 courses of 3 weekly Carboplatin (AUC 5) and paclitaxel (155mg/m2) is allowed according to the departmental policy.
•6. Contra indications to MRI.
•7.Contra indications to BT.

发起方