NCT04227535进行中（未招募）不适用
Deciphering Rheumatoid Arthritis-associated Interstitial Lung Disease Pathogenesis 2
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 509
- 试验地点
- 1
- 主要终点
- Identification of genetic factors implicated in RA-ILD using whole exome sequencing (WES).
研究概览
简要总结
The overall goal of this study is to identify risk and prognosis factors of Interstitial Lung Disease (ILD) in patients with rheumatoid arthritis (RA).
详细描述
This is not an interventional study. This is a study designed to recruit individuals affected by RA and investigate associated ILD to better understand the clinical phenotypes and genetic/molecular endotypes of RAILD, including the prognosis of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •RA diagnosis according to ACR (classification of rheumatoid arthritis) 1987 and/or ACR/EULAR 2010 criteria, validated by a senior rheumatologist
- •ILD diagnosis based on typical High-Resolution Computed-Tomography (HCRT) patterns and pulmonary function tests (PFT), validated by a senior pulmonologist
排除标准
- •Lack of signed informed consent
- •SELECTION OF CONTROLS:
- •Inclusion Criteria:
- •Age ≥18 years
- •RA diagnosis according to ACR 1987 and/or ACR/EULAR 2010 criteria, validated by a senior rheumatologist
- •Exclusion Criteria:
- •Lack of signed informed consent
结局指标
主要结局
Identification of genetic factors implicated in RA-ILD using whole exome sequencing (WES).
时间窗: Baseline
whole exome sequencing data
次要结局
- Describe RA-ILD natural history by a 5 years annual follow up of RA-ILD patients.(Every year during 5 years)
- Description of the effect of disease modifying Anti Rheumatic Drugs (DMARDs) on ILD course and mortality.(Every year during 5 years)
- Identification of genetic factors implicated in RA-ILD using genome wide association study.(Baseline)
研究者
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Rheumatoid Arthritis Patients at Risk for Interstitial Lung DiseaseRheumatoid ArthritisInterstitial Lung DiseaseNCT03297775University of Colorado, Denver750
Unknown
不适用
Interstitial Lung Disease in Early Rheumatoid ArthritisRheumatoid ArthritisInterstitial Lung DiseaseNCT03977415National Jewish Health76
招募中
不适用
Early Rheumatoid Arthritis Lung Disease StudyRheumatoid ArthritisNCT03192267University of Nebraska125
已完成
不适用
Developing a Screening Tool for Interstitial Lung Disease in People With Rheumatoid Arthritis Using Risk FactorsArthritis, RheumatoidLung Diseases, InterstitialNCT05855109Boehringer Ingelheim1,304
招募中
不适用
dEtection of rheumAtoid aRthritis - Interstitial Lung dIseasE by Thoracic ultRasoundThoracic UltrasoundLung UltrasoundRheumatoid ArthritisInterstitial Lung DiseaseNCT06235645University Hospital, Tours280