Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation

Not Applicable

Recruiting

• Conditions: Propofol
• Interventions: Drug: Dexmedetomidine-Propofol; Drug: Ketamine-Propofol

• Registration Number: NCT06756594
• Lead Sponsor: Sohag University

Brief Summary

This study aims to compare efficacy of sedation between Dexmedetomidine-Propofol and Ketamine-Propofol combinations in the upper or lower gastrointestinal system endoscopy. We compare between 2 combinations as regard hemodynamic stability, post operative side effects as occurrence of delirium, nausea, vomiting, headache, hallucination or agitation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-11
• Study Start: 2024-11-12
• Study First Submitted: 2024-12-26
• Study First Submitted QC: 2024-12-26
• Last Update Submitted: 2024-12-26
• Study First Posted: 2025-01-03
• Last Update Posted: 2025-01-03
• Primary Completion: 2025-06-11
• Study Completion: 2025-06-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• American Society of Anesthesiologists physical status I to II.
• Age between 18 and 60 years.
• Both sexes.

Exclusion Criteria

• Having severe heart, lung, liver disease, kidney failure, or bleeding disorder.
• Patients having fever, hypothermia or infection, electrolyte disorders, such as hypokalemia and hypocalcaemia, acid-base disorder, allergy to drugs to be used.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dexmedetomidine-Propofol for sedation during gastrointestinal endoscopy	Dexmedetomidine-Propofol	efficacy of sedation with Dexmedetomidine-Propofol combination in the upper or lower gastrointestinal system endoscopy.
Ketamine-Propofol for sedation during gastrointestinal endoscopy	Ketamine-Propofol	efficacy of sedation with Ketamine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

Primary Outcome Measures

Name	Time	Method
intraoperative and postoperative monitoring of sedation during upper or lower gastrointestinal system endoscopy.	every 5 minutes intraoperative and every 15 minutes for 2 hours postoperative.	Sedation level

Trial Locations

Locations (1)

Sohag University Hospital; 🇪🇬 Sohag, Egypt