Early Endoscopic Indicators for OACs After Lung Transplantation: Development of a Novel Mucosal Healing Score
- Conditions
- Airway Complication Which Require Any Intervention
- Registration Number
- NCT00940147
- Lead Sponsor
- Thomas Fuehner
- Brief Summary
Airway complications are a significant cause of morbidity after lung transplantation (LTx). Bronchoscopic evaluation may help to identify risk factors for requiring interventions later.
- Detailed Description
The investigators evaluated lung transplant recipients prospectively. Adult patients surviving 90 day after LTx will be included. The investigators propose a classification of airway healing based on the endoscopic bronchial appearances at days 7, 14, 21, 90, 180 and 365 after LTx. A score system including mucosal healing, full tissue necrosis (=dehiscence), lose sutures, fibrin plugs, polyps and malacia will be developed (max. score 8 points/date). Endoscopic findings will be correlated with the development of obstructive airway complications (OAC, requiring \>1 intervention). Afterwards the new score system will be applied prospectively in the patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 180
- 3 month survivor after LTx
- no OAC
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary endpoint of this study was any obstructive airway complication (AC) which required desobliterative intervention. 1 year
- Secondary Outcome Measures
Name Time Method secondary endpoint included anastomosis-related death. 1 year
Trial Locations
- Locations (1)
Hannover Medical School
🇩🇪Hannover, Germany