The Role of Interferon-gamma in Immune Responses to Invasive Candidiasis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 87
- 试验地点
- 1
- 主要终点
- All-cause mortality
研究概览
简要总结
The purpose of the study is to investigate the role of the human immune response to candidemia/invasive candidiasis as it relates to the cytokine interferon-gamma.
详细描述
In this study, patients with Candida bloodstream infection, peritonitis/intra-abdominal abscess, and pleural empyema will be enrolled.
Persistent candidiasis confirmed by culture will be defined as follows: (i) Candida bloodstream infection present for >48 hours after initiation of effective antifungal treatment and after removal of intravenous devices, (ii) Intra-abdominal infection (peritonitis or abscess) that persists for >96 hours after source control intervention and effective antifungal treatment, (iii) Pleural empyema that persists for >96 hours after placement of drainage catheter and effective antifungal treatment.
Outcomes in patients with and without persistent candidiasis will be assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
All-cause mortality
时间窗: 30 days
All-cause mortality
次要结局
- Plasma IFN-gamma concentration after dual innate and adaptive immune system stimulation by QuantiFERON Monitor assay(1 week)
- In vitro antifungal activity of polymorphonuclear leukocytes in the presence or absence of interferon-gamma by colorimetric method(1 week)
- Serum concentration of IFN-gamma and other cytokines by multiplex ELISA(1 week)
- Intracellular expression of IFN-gamma expression by a CD8 T-cell competence assay(1 week)
研究者
Paschalis Vergidis
Principal Investigator
Mayo Clinic