Study of Time-restricted Eating on Weight Loss.

Not Applicable

Completed

Interventions: Behavioral: Consistent Meal timing plan
Behavioral: Time-restricted Eating plan

Brief Summary: This is a randomized controlled trial studying the effects of time-restricted eating (TRE) on weight loss in obese humans. Obesity is the number one risk factor for type 2 Diabetes Mellitus (T2DM), and numerous studies demonstrate that weight loss is an effective strategy to prevent T2DM and improve the metabolic health of people diagnosed with T2DM. Unfortunately, classical calorie restriction diets often fail to produce long-term weight loss due to low compliance, reduced resting metabolic rate (RMR), and other factors. Therefore, novel dieting techniques must be explored in order to successfully treat obesity and prevent T2DM. Studies in mice provide compelling evidence that feeding/fasting cycles can be altered to produce beneficial effects on weight loss and metabolic health markers in the absence of calorie restriction. Limited research in human subjects suggests that this feeding paradigm may translate to human health as well, however, more research needs to be done in order to confirm this hypothesis. This study will determine if TRE can lead to weight loss in obese human subjects. Secondary outcomes include changes in body composition, HOMA-IR, hormonal and biochemical serum markers, RMR, and total energy expenditure (TEE).

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
Consistent Meal Timing Plan	Consistent Meal timing plan	Participants in this group will be instructed to eat three daily meals during specified eating times. Their first meal will be between 7am-11am. Second meal between 11am and 3pm, and third meal between 4pm-10pm. Participants will be encouraged to eat small snacks if needed so that they can eat their next meal during the specified window.
Time-restricted eating plan	Time-restricted Eating plan	Participants in this group will be instructed to fast every day from 8pm until 12pm the following day. From 12pm until 8pm, participants can eat and drink whatever they want. During fasting hours, participants can drink water and black coffee.

Primary Outcome Measures

Name	Time	Method
Weight Loss	Daily for 12 weeks	Measure changes in weight during the 12 week study

Secondary Outcome Measures

Name	Time	Method
Changes in HbA1c levels	Measured twice: Once at study start and once 12 weeks later	WIll measure HbA1c levels prior to diet intervention and again at study completion
Changes in lean mass	Measured twice: Once at study start and once 12 weeks later	Measure changes in lean mass during the 12 week study using DXA data
Fasting insulin levels	Measured twice: Once at study start and once 12 weeks later	Measure fasting insulin levels pre and post intervention
Resting metabolic rate	Measured twice: Once at study start and once 12 weeks later	Will measure participants resting metabolic rate
Fat loss	Measured twice: Once at study start and once 12 weeks later	Measure changes in fat mass during the 12 week study using DXA data
Total energy expenditure	Measured twice: Once at study start and once 12 weeks later	Will measure participants total energy expenditure during the week leading up to the study start and during the final week of the study
Changes in fasting glucose levels	Measured twice: Once at study start and once 12 weeks later	WIll measure fasting blood glucose levels prior to diet intervention and again at study completion

Locations (1): UCSF Medical Center
🇺🇸
San Francisco, California, United States