CT Evaluation of Cardiovascular Risk Markers in Obese Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 123
- 试验地点
- 1
- 主要终点
- Epicardial fat evaluation in obese population
研究概览
简要总结
Obesity is a chronic metabolic disorder : it leads to coronary heart disease and early atherosclerosis.
Coronary artery calcium measured by CT is known as a robust predictor to predict risk for cardiac events in symptomatic and asymptomatic individuals. Furthermore, recent studies show that other CT risk factor exists, independent of calcium scoring, such as epicardial fat, intrathoracic fat and visceral fat.
The aim of this prospective study is to evaluate these new cardiovascular risk markers in obese patients, using standard dose CT and low dose CT with adaptative statistical iterative reconstruction.
详细描述
In this prospective single-center study, obese patients of our clinical nutrition service, hospitalized for nutritional assessement, are included.
All unenhanced coroCT examinations are performed on the same 64-Row CT scanner (discovery CT 750 HD scanner, GE Healthcare), using prospective ECG-triggerring. The investigation protocol began with a standard-dose acquisition followed immediately by a low-dose acquisition, recorded over strictly identical segments (identical first and last sections).
After these two examinations, estimated dose values are less than the diagnostic scan reference level for a coroCT.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •obesity >30 indicated non enhanced coroCT for calcium scoring.
排除标准
- •low Framingham scoring
- •pregnancy
- •not providing informed consent
- •history of cardiovascular disease.
结局指标
主要结局
Epicardial fat evaluation in obese population
时间窗: at day 1
次要结局
- Calcium scoring evaluation(at day 1)