Investigations of the changes in overactive bladder symptoms after the discontinuation of drug for overactive bladder in benign prostatic hyperplasia patients with coexisting overactive bladder

Not Applicable

Completed

Conditions: Diseases of The genitoruinary system

Registration Number: KCT0000392

Lead Sponsor: Kangwon National University Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Male

Target Recruitment: 120

Inclusion Criteria

Elligible patients are men 45 years or older with a total International Prostate Symptom Score (IPSS) of 8 or higher, a total overactive bladder symptoms score (OABSS) of 3 or higher and a score of 3rd item (urgency) of the OABSS of at least 2, and findings suggestive of BPH on transrectal ultrasonography.

Exclusion Criteria

Those with acute urinary tract infection, significant renal dysfunction, significant hepatic dysfunction, a history of stroke or Parkinsonism, or a history of prostate cancer or PSA of 10ng/ml or more will be excluded.
And those with postvoid residual urine (PVR) more than 100ml, or maximum flow rate less than 8ml/s will be excluded

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
OABSS (overactive bladder symptoms score);PPBC (the patient perception of bladder condition);storage symptom score of IPSS (international prostate symptom score);QOL score

Secondary Outcome Measures

Name	Time	Method
total micturitions per 24 hours on frequency-volume chart;micturitions per night on frequency-volume chart;functional bladder capacity on frequency-volume chart;voiding symptom score of IPSS;maximum flow rate on uroflowmetyr;postvoid residual urine;patients' intention of resuming administration of solifenacin;adverse events