NCT01584206已完成不适用
Assessment of Sterol Metabolism in Sitosterolemia: A Pilot Study of Patients Treated With Ezetimibe
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Plasma cholesterol level
研究概览
简要总结
Ezetimibe has become the treatment choice for patients with sitosterolemia. Ezetimibe is an inhibitor of cholesterol absorption from the gastrointestinal tract. The purpose of this study is to determine if ezetimibe improves whole body plant sterol and cholesterol homeostasis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 99 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •confirmed diagnosis of homozygous sitosterolemia as established by genotyping and clinical parameters
排除标准
- •intellectual disability
- •major infectious diseases
- •immunodeficiency
- •renal failure
研究组 & 干预措施
Ezetimibe
Experimental
Compare on and off ezetimibe
干预措施: Ezetimibe (Drug)
结局指标
主要结局
Plasma cholesterol level
时间窗: 8 months
Plasma cholesterol level will be assessed by GC
Plasma sitosterol level
时间窗: 8 months
Plasma plant sterol assessment using GC
次要结局
- Cholesterol synthesis(4 months)
- Cholesterol absorption(4 month)
研究者
研究点 (1)
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