NCT07345702
Not yet recruiting
Not Applicable
Endovascular Versus Medical Therapy for Acute Large-Core Basilar Artery Occlusion: A Multicenter Retrospective Registry Study (BAOCHE-LC)
Xuanwu Hospital, Beijing1 site in 1 country518 target enrollmentStarted: January 31, 2026Last updated:
InterventionsEndovascular Therapy
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Xuanwu Hospital, Beijing
- Enrollment
- 518
- Locations
- 1
- Primary Endpoint
- Proportion of Patients Achieving mRS 0-3 at 90 Days
Overview
Brief Summary
This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion. It also investigates clinical, imaging, and laboratory factors associated with functional outcomes and mortality. Patients are grouped according to the treatment received in routine clinical practice.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age ≥18 years, men or women.
- •Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.
- •Time from symptom onset (or last known well) to treatment (endovascular therapy or medical therapy) ≤7 days.
- •Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 0-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.
Exclusion Criteria
- •Subjects with occlusions in both anterior and posterior circulation.
- •CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed).
- •Missing key clinical information (e.g., unavailable baseline NIHSS, unclear symptom onset/last known well time, or missing major treatment information including whether EVT was performed).
- •Baseline NIHSS score \<
- •Woman of childbearing potential who is known to be pregnant or lactating or who has a positive pregnancy test on admission.
- •Missing follow-up outcomes at 90 days.
- •Any other condition judged by investigators to substantially affect analysis or interpretation.
Arms & Interventions
Endovascular Therapy
Intervention: Endovascular Therapy (Procedure)
Best Medical Treatment Alone
Outcomes
Primary Outcomes
Proportion of Patients Achieving mRS 0-3 at 90 Days
Time Frame: 90 days
The modified Rankin scale (range, 0 \[no symptoms\] to 6 \[death\]). Higher scores mean a worse outcome.
Secondary Outcomes
- Ordinal Shift analysis of mRS at 90 days(90 days)
- All-Cause Mortality at 90 Days(90 days)
- Symptomatic Intracranial Hemorrhage(24 (-2/+12) hours)
- Proportion of Patients Achieving mRS 0-3 at 1 year(1 year)
Investigators
Chuanhui Li
Associate Professor, Xuanwu Hospital, Captimal Medical University
Xuanwu Hospital, Beijing
Study Sites (1)
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