NCT07345702招募中不适用
Endovascular Versus Medical Therapy for Acute Large-Core Basilar Artery Occlusion: A Multicenter Retrospective Registry Study (BAOCHE-LC)
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 518
- 试验地点
- 2
- 主要终点
- Proportion of Patients Achieving mRS 0-3 at 90 Days
研究概览
简要总结
This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion. It also investigates clinical, imaging, and laboratory factors associated with functional outcomes and mortality. Patients are grouped according to the treatment received in routine clinical practice.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years, men or women.
- •Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.
- •Time from symptom onset (or last known well) to treatment (endovascular therapy or medical therapy) ≤7 days.
- •Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 0-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.
排除标准
- •Subjects with occlusions in both anterior and posterior circulation.
- •CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed).
- •Missing key clinical information (e.g., unavailable baseline NIHSS, unclear symptom onset/last known well time, or missing major treatment information including whether EVT was performed).
- •Baseline NIHSS score <
- •Woman of childbearing potential who is known to be pregnant or lactating or who has a positive pregnancy test on admission.
- •Missing follow-up outcomes at 90 days.
- •Any other condition judged by investigators to substantially affect analysis or interpretation.
研究组 & 干预措施
Best Medical Treatment Alone
Endovascular Therapy
干预措施: Endovascular Therapy (Procedure)
结局指标
主要结局
Proportion of Patients Achieving mRS 0-3 at 90 Days
时间窗: 90 days
The modified Rankin scale (range, 0 \[no symptoms\] to 6 \[death\]). Higher scores mean a worse outcome.
次要结局
- Rate of All-Cause Mortality at 90 Days(90 days)
- Rate of Symptomatic Intracranial Hemorrhage(24 (-2/+12) hours)
- Ordinal Shift analysis of mRS at 90 days(90 days)
- All-Cause Mortality at 90 Days(90 days)
- Symptomatic Intracranial Hemorrhage(24 (-2/+12) hours)
- Proportion of Patients Achieving mRS 0-3 at 1 year(1 year)
研究者
Chuanhui Li
Associate Professor, Xuanwu Hospital, Captimal Medical University
Xuanwu Hospital, Beijing
研究点 (2)
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