Intranasal white petrolatum versus chlorhexidine to reduce postoperative infections in dermatologic surgery

Phase 2

Recruiting

• Conditions: Incidence of postoperative wound infections; Prevalance of staphylococcus aureus carriage; Skin Cancer; Surgery - Other surgery; Cancer - Non melanoma skin cancer; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12612001051831
• Lead Sponsor: Eugene Tan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-10-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

Patients scheduled for elective dermatologic surgery for removal of skin cancer.

Exclusion Criteria

Current infection
Current antibiotic therapy
Antibiotic use in the last month
Failure to have intranasal swab to assess carriage of S. aureus prior to surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the efficacy of intranasal application of white petrolatum or chlorhexidine for reducing wound infections. The incidence of wound infections in the group using white petrolatum or chlorhexidine in the anterior nares (nostrils) will be compared to the incidence of wound infections in the group using normal saline.[12 months after randomisation]

Secondary Outcome Measures

Name	Time	Method
To determine the prevalance of nasal carriage of staphylococcus aureus. The number of nasal swabs being positive (positive culture for growth) for staphylococcus aureus amongst the entire study population will be reported.[12 months after randomisation];To determine which patients would benefit most from this approach if proven to be effective. A subgroup analysis would be performed to determine if there are any patient related factors (eg. Age, recent hospitalisation etc) which would place the patient at high risk for intranasal staphylococcus aureus carriage or high risk of post-operative wound infections.[12 months after randomisation];To prove the cost-effectiveness of this method to reduce wound infections. The cost of intranasal white petrolatum and 2% chlorhexidine would be compared against the cost of managing post-operative wound infection.[12 months after randomisation]