Implementation of biomimetic 3D bioprinting technology in selecting optimal regimens as adjuvant therapy to prevent hepatocellular carcinoma recurrence after liver resection or ablation: a feasibility study

未提供1 个研究点分布在 1 个国家开始时间: 2025年12月15日最近更新: 2025年12月15日

适应症

试验速览

阶段: Unknown
状态: 招募中
试验地点: 1
主要终点: Efficacy of Live-in-Cube in guiding the selection of optimal adjuvant treatment

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

To evaluate the efficacy of biomimetic 3D bioprinting technology in guiding the selection of optimal adjuvant treatment regimens to prevent hepatocellular carcinoma (HCC) recurrence after curative liver resection.

研究设计

研究类型: Observational

入排标准

年龄范围: 18 至 —（—）
性别: All

入选标准

•Age >= 18 years at the time of screening;
•2.Diagnosis of HCC;
•3.Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0 or 1;
•With or without prior locoregional therapy such as transarterial chemoembolisation (TACE), radiofrequency ablation (RFA), and stereotactic body radiation therapy (SBRT) before surgery;
•5.Meet any item indicating higher risk of tumour recurrence: any tumour size >= 5cm, number of tumour >= 3, presence of microvascular or marcovascular invasion, or poor tumour differentiation;
•6.No prior systemic therapy for HCC;
•No other active malignancies within 5 years, except malignancies with a negligible risk of metastasis or death (eg. 5-year overall survival rate > 90%), such as adequately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, localised prostate cancer, ductal carcinoma in situ, or stage I uterine cancer;
•Willing and able to provide written informed consent for the collection and usage of biological samples.

排除标准

•1.Non-HCC diagnosis, including fibrolamellar HCC, sarcomatoid HCC, mixed HCC cholangiocarcinoma etc;
•2.Fail to give consent or refusal to take part in the study;
•3.Child-Pugh class C liver cirrhosis;
•4.Receipt of any prior systemic therapy for HCC.

研究组 & 干预措施

single arm

结局指标

主要结局

Efficacy of Live-in-Cube in guiding the selection of optimal adjuvant treatment

Recurrence rate

次要结局

Disease free survival
Overall survival

研究者

发起方

未提供

研究点 (1)

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