Influence of early goal-directed therapy using arterial waveform cardiac output measurement in high-risk surgery.
- Conditions
- early goal-directed therapy (EGDT)cardiac outputarterial waveform analysishigh-risk surgeryabdominal surgery
- Registration Number
- NL-OMON24432
- Lead Sponsor
- Division of Vital FunctionsUniversity Medical Center Utrecht
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 542
Inclusion Criteria
1. Patients undergoing the following elective operations, irrespective of their ASA status:
A. Esophagectomy;
Exclusion Criteria
1. Patients in which cardiac output measurement is indicated;
2. Age < 18 years;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome is a combined endpoint of the number of major complications within the first 30 days after surgery:<br /><br>1. Mortality (any cause);<br /><br>2. Cardiac arrest;<br /><br>3. Myocardial infarction;<br /><br>4. Pulmonary edema;<br /><br>5. Stroke;<br /><br>6. Prolonged mechanical ventilation (>24 hrs);<br /><br>7. Pulmonary embolism;<br /><br>8. Pneumonia;<br /><br>9. Respiratory failure (requiring mechanical ventilation);<br /><br>10. Acute kidney injury;<br /><br>11. Anastomotic leak;<br /><br>12. Re-operation;<br /><br>13. Wound infection;<br /><br>14. Sepsis.<br /><br>These major complications are associated with an increased 30-day and long-term mortality.
- Secondary Outcome Measures
Name Time Method