Identifying Prostate Brachytherapy Seeds Using MRI

Not Applicable

Completed

• Conditions: Prostate Cancer Patients Who Have Brachytherapy Seed Implant
• Interventions: Other: MRI Scan

• Registration Number: NCT01878058
• Lead Sponsor: University Health Network, Toronto

Brief Summary

This study will look at the feasibility of using a type of Magnetic Resonance Imaging called Susceptibility Weighted Imaging (SWI) to detect your implanted radioactive seeds. Researchers hope that using SWI will eliminate the need to use CT imaging to detect your implanted radioactive seeds.

This study will also see if the MRI seed detection is as effective as current standard practice of seed detection (routine MRI and CT imaging). This technique would be beneficial for brachytherapy without the need to fuse the MRI and CT images, as is done currently.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2012-10-23
• Study First Submitted QC: 2013-06-11
• Study First Posted: 2013-06-14
• Primary Completion: 2016-08
• Study Completion: 2016-08
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-31
• Last Update Posted: 2016-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

1. At least 18 years old
2. Histologic diagnosis of adenocarcinoma of the prostate
3. No contraindications for Pelvic body MRI
4. Patients undergoing LDR brachytherapy at PMH and scheduled for post implant analysis with CT-MR (standard at PMH)
5. Ability to provide written informed consent to participate in the study

Exclusion Criteria

1. Contraindication for Pelvic body MRI
2. Patient not willing/consenting for this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
MRI Scan	MRI Scan	Patients will receive an extra MRI scan in addition to their routine scan.

Primary Outcome Measures

Name	Time	Method
Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will reduce registration errors	6 months
Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will reduce planning time for the post-implant plan	6 months
Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will eliminate the CT scan of the patient.	6 months

Secondary Outcome Measures

Name	Time	Method
Compare the differences in MR seed identification using the MR pulse sequence vs. CT images.	6 months	Our goal is to perfectly match these two modalities with acceptance test of 97%. This technique would be beneficial for LDR (Low Dose Rate) Brachytherapy without need to fuse the CT and MR images and eliminate any image registration uncertainly.

Trial Locations

Locations (1)

University Health Network, The Princess Margaret; 🇨🇦 Toronto, Ontario, Canada