Host-pathogen interaction study on non-tuberculous mycobacteria in children - Children-NTM

niversitätsklinikum Freiburg Institut für Immundefizienz0 个研究点目标入组 138 人开始时间: 2011年2月10日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Children with NTM infection defined as follows:
•1) Probable infection
•Unilaterarally enlarged lymph node >= 2cm in diameter plus TST skin test > 5 mm plus exclusion of tuberculosis/ malignant lymphoma/ bartonellosis
•2) Confirmed NTM infection
•a) Lymph node biopsy with histology typical for mycobacteria plus positive culture or PCR for NTM
•b) Draining lymphnode plus positive smear (culture or PCR) for NTM
•Controls will be matched by age, sex, region, and – if possible – by ethnicity. The second unmatched control group will consist of children with diagnosed Bartonella henselae infection (specific antibody (IgG) titre > 1:265 in the course of the disease).

•1) Lack of informed consent of parent(s) or lack of assent of patient
•2) Malignom/lymphoma, lymphoproliferative disease, detection of other pathogens (particularly Bartonella henselae (by culture, PCR or serology), tuberculosis (IGRA, Ellispot or x-ray chest for TB exclusion), detection of acute infections with other pathogens by culture, PCR or serology (Toxoplasmosis, infections with actinomycetes, Nocardia, CMV, EBV, HIV).
•3) Children hospitalized due to immune or infection related conditions will not be eligible as controls for this study

发起方

niversitätsklinikum Freiburg Institut für Immundefizienz